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Monday, July 2, 2007 1:21 PM EDT
July 2: Officials fear 'wasting disease' in animals



Here is some more information about the "wasting disease":

Chronic Wasting Disease (CWD) is a transmissible neurological disease of deer and elk that produces small lesions in brains of infected animals. It is characterized by loss of body condition, behavioral abnormalities and death. CWD is classified as a transmissible spongiform encephalopathy (TSE), and is similar to mad cow disease in cattle and scrapie in sheep.

Infectious agents of CWD are neither bacteria nor viruses, but are hypothesized to be prions. Prions are infectious proteins without associated nucleic acids.

Although CWD is a contagious fatal disease among deer and elk, research suggests that humans, cattle and other domestic livestock are resistant to natural transmission. While the possibility of human infection remains a concern, it is important to note there have been no verified cases of humans contracting CWD.

CWD can reduce the growth and size of wild deer and elk populations in areas where the prevalence is high, and is of increasing concern for wildlife managers across North America. The disease was long thought to be limited in the wild to a relatively small endemic area in northeastern Colorado, southeastern Wyoming and southwestern Nebraska, but has recently been found in several new areas across the North American continent. The disease also has been diagnosed in commercial game farms in several states and provinces.

WHAT IS CHRONIC WASTING DISEASE?

Chronic Wasting Disease (CWD) is a contagious neurological disease affecting deer and elk. It causes a characteristic spongy degeneration of the brains of infected animals resulting in emaciation, abnormal behavior, loss of bodily functions and death.

CWD belongs to a group of diseases known as transmissible spongiform encephalopathies (TSEs). Within this family of diseases, there are several other variants that affect domestic animals: scrapie, which has been identified in domestic sheep and goats for more than 200 years, bovine spongiform encephalopathy (BSE) in cattle (also known as "mad cow disease"), and transmissible mink encephalopathy in farmed mink.

Several rare human diseases are also TSEs. Creutzfeldt-Jakob disease (CJD) occurs naturally in about one out of every one million people worldwide. Variant Creutzfeldt-Jakob disease (v-CJD) has been associated with the large-scale outbreak of BSE in cattle herds in Great Britain.

WHAT WILDLIFE SPECIES ARE AFFECTED BY CWD?

Only four species of the deer family are known to be naturally susceptible to CWD: elk, mule deer, white-tailed deer and moose (see below). Susceptibility of other members of the deer family (cervids) and other wildlife species is not known, although ongoing research is further exploring this question.

One case of a hunter harvested bull moose in Colorado tested positive for chronic wasting disease in September 2005.

CAN HUMANS GET CWD?

Though many observers try to compare CWD with "mad cow disease", they are distinctly different. Currently, there is no evidence that CWD poses a risk for humans; however, public health officials recommend that human exposure to the CWD infectious agent be avoided as they continue to evaluate any potential health risk.

The World Health Organization has reviewed available scientific information and concluded that currently there is no evidence that CWD can be transmitted to humans. During the period 1997-1998, three cases of sporadic Creutzfeldt-Jakob disease (CJD) occurred in the U.S. in young adults. These individuals had consumed venison. This led to speculation about possible transmission of CWD from deer or elk to humans. However, review of the clinical records and pathological studies of all three cases by the Centers for Disease Control and Prevention in Atlanta, Georgia, did not find a causal link to CWD.

Nonetheless, health and wildlife officials advise caution. Hunters are encouraged not to consume meat from animals known to be infected. In addition, hunters should take common sense precautions when field dressing and processing deer or elk taken in areas where CWD is found.

WHAT CAUSES CWD?

The most widely accepted theory is that the agent is a prion, an abnormal form of cellular protein that is most commonly found in the central nervous system and in lymphoid tissue. The prion "infects" the host animal by promoting conversion of normal cellular protein to the abnormal form.

The CWD infectious agent is smaller than most viral particles and does not evoke any detectable immune response or inflammatory reaction in the host animal. Based on experience with other TSE agents, the CWD infectious agent is assumed to be resistant to enzymes and chemicals that normally break down proteins, as well as resistant to heat and normal disinfecting procedures.






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