The 192-mile ride includes more than 6,300 cyclists from 43 states and 10 countries ranging in age from 13 to 85.
The event includes 914 riders and volunteers that are cancer survivors or current patients themselves.
The Challenge has 12 different routes that pass through 46 towns. The average cyclist raises more than $7,000.
The PMC donates 100 percent of every rider-raised dollar directly to Dana-Farber through the its fundraising arm, the Jimmy Fund.
It is the institute’s largest single contributor, raising more than 53 percent of the Jimmy Fund’s annual revenue, according to a press release from event organizers.
In 2017, the PMC gave a record gift of $51 million to Dana-Farber, bringing it’s 38-year contribution to a total of more than $598 million since its inception in 1980.